Prospective medical assessment of adults surviving childhood cancer: Study design, cohort characteristics, and feasibility of the St. Jude Lifetime Cohort Study

• DOI: 10.1002/pbc.22875
• Publication Date: 2010-12-15T17:51:56Z
• Authors: Melissa M. Hudson; Kirsten K. Ness; Vikki G. Nolan; Gregory T. Armstrong; Daniel M. Green; E. Brannon Morris; Sheri L. Spunt; Monika L. Metzger; Kevin R. Krull; James L. Klosky; Deo Kumar Srivastava; Leslie L. Robison
• Keywords: Pediatric cancer; Childhood Cancer

Abstract Background To facilitate prospective medical assessment of adults surviving pediatric malignancies and advance knowledge about long‐term childhood cancer survivor health, St. Jude Children's Research Hospital (SJCRH) is establishing a lifetime cohort survivors. Methods Eligibility criteria for inclusion in the Lifetime Cohort (SJLIFE) study include: (1) diagnosis malignancy treated at SJCRH; (2) survival ≥ 10 years from diagnosis; (3) current age ≥18 years. Three levels participation are offered: comprehensive evaluation on SJCRH campus; limited home evaluation; or completion health surveys only. A systematic recruitment structure based upon blocks 50 patients initially focused leukemia lymphoma survivors eligible pilot studies. Results As January 1, 2010, 1,625 (42%) 3,900 ≥10‐year have been contacted. Among first 1,000 potentially selected recruitment, 971 were subsequently confirmed to fulfill eligibility criteria. date, 898/971 (92.5%) successfully contacted whom 825 (91.8%) agreed participate. participants, 88.6% evaluation, 0.4% local 11.0% survey Anticipated minimum overall rate 75.3% (731/971). Comparison those who versus declined participate revealed greater proportion males ( P = 0.001). Conclusions Early results SJLIFE support its feasibility recruit aging research investigations evaluating late outcomes by assessments. Pediatr Blood Cancer 2011;56:825–836. © 2010 Wiley‐Liss, Inc.