Factors relating to pregnancy and birth and the risk of childhood brain tumors: Results from an Australian case-control study

• DOI: 10.1002/pbc.24751
• Publication Date: 2013-08-26T10:36:46Z
• Authors: Kathryn R Greenop; Eve M Blair; Carol Bower; Bruce K Armstrong; Elizabeth Milne
• Keywords: Mass index

Background Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their causes largely known. This study investigated association between maternal and birth characteristics risk CBT. Procedures Cases families were recruited from all 10 Australian pediatric oncology centers 2005 2010. Control via random-digit dialing, frequency matched to cases on basis child's age, sex, State residence. Maternal children ascertained by questionnaires. Odds ratios (ORs) 95% confidence intervals (CI) estimated using unconditional logistic regression, adjusting for relevant confounders. Results For this analysis, data 319 case 1,079 control available. No was found CBT weight, fetal growth, order, gestational or body mass index. The ORs inadequate excessive weight gain (GWG) (Institute Medicine 2009 guidelines) 1.8 (95% CI 1.2–2.6) 1.4 1.0–2.1), respectively; similar findings GWG seen across categories index height, smoking, parental education. Risk low grade glioma appeared increased with preterm (OR 1.6 0.8–3.1) admission neonatal intensive care (NICU) >2 days 1.7, 0.9–3.6). Conclusion We little evidence associations most characteristics. we observed GWG, prematurity NICU require corroboration other studies. Pediatr Blood Cancer 2014;61:493–498. © 2013 Wiley Periodicals, Inc.