Early and late adverse effects of radioiodine for pediatric differentiated thyroid cancer

• DOI: 10.1002/pbc.26595
• Publication Date: 2017-04-24T12:25:45Z
• Authors: Domenico Albano; Francesco Bertagna; Maria Beatrice Pa...; Raffaele Giubbini
• Keywords: Sialadenitis; Cumulative dose; Bone marrow suppression; Late effect; Dry mouth

Abstract Background Radioiodine‐131 (I131) therapy for differentiated thyroid cancer (DTC) is generally a safe and effective treatment, but it has some potential side effects, which have been well described in adults less analyzed children. Our aim was to describe early late adverse events of radioactive I131 pediatric patients. Methods All consecutive patients ≤18 years treated DTC the period 1980–2015 were retrospectively effects radioiodine. Early include nausea/emesis, radiation thyroiditis, sialadenitis, dry mouth, transient bone marrow (BM) suppression. Late complications permanent salivary gland dysfunction, BM suppression, pulmonary fibrosis, second cancers, fertility problems. Results One hundred five with our department total amount 302 radioiodine treatments. In total, 127 recorded: 44 episodes nausea/emesis; 30 sialoadenitis, 24 18 11 correlated radioactivity administered any treatment. Twelve children developed ≥1 complication 20 complications: two four malignancies, alterations. events, except alterations, number therapies cumulative activities I131. Conclusions conclusion, are associated administrated each while treatments radioiodine,