Fetal akinesia and associated abnormalities on prenatal MRI

• DOI: 10.1002/pd.2724
• Publication Date: 2011-03-04T10:03:10Z
• Authors: Stefan F. Nemec; Romana Höftberger; Ursula Nemec; Dieter Bettelheim; Peter C. Brugger; Gregor Kasprian; Gabriele Amann; Siegfried Rotmensch; John M. Graham Jr.; David L. Rimoin; Daniela Prayer
• Keywords: Polyhydramnios; Pulmonary Hypoplasia

Abstract Objective In view of the increasing role magnetic resonance imaging (MRI) as an adjunct to prenatal ultrasonography (US), this study sought demonstrate visualization fetal akinesia and associated abnormalities on MRI. Methods This retrospective included six fetuses with abnormalities, depicted MRI after suspicious US. The whole fetus was assessed for musculoskeletal pathological conditions elsewhere. Fetal outcome data were compared imaging. US findings also compared. Results Akinesia resulting in arthrogryposis seen 6/6 fetuses, abnormal musculature 5/6 fetuses. Associated brain found 2/6 fetuses; facial 3/6; lung hypoplasia polyhydramnios 2/6. There pregnancies that terminated one individual died neonatally. autopsy concordant 4/6 cases. body 1/6 cases cases, revealed additional abnormalities. addition US, correctly identified central nervous system four three Conclusion Our results which may have impact perinatal management, Copyright © 2011 John Wiley & Sons, Ltd.