Assessing recording delays in general practice records to inform near real-time vaccine safety surveillance using the Clinical Practice Research Datalink (CPRD)

• DOI: 10.1002/pds.4173
• Publication Date: 2017-02-03T12:07:20Z
• Authors: Andreia Leite; Nick J. Andrews; Sara L. Thomas
• Keywords: Vaccine safety; Clinical Practice

Purpose Near real-time vaccine safety surveillance (NRTVSS) is an option for post-licensure assessment. NRTVSS requires timely recording of outcomes in the database used. Our main objective was to examine delays Clinical Practice Research Datalink (CPRD) interest inform feasibility using these data. We also evaluated completeness and further assessed reporting hospitalized events CPRD. Methods selected Guillain–Barré syndrome (GBS), Bell's palsy (BP), optic neuritis (ON) febrile seizures (FS), from January 2005 June 2014. (e.g. due feedback specialist referral) stand-alone CPRD by comparing event system dates excluding >1 year. used linked CPRD-hospitalization data evaluate Results Among 51 220 patients analysis (GBS: n = 830; BP: 12 602; ON: 1720; FS: 36 236), most had a record entered within 1 month date 73.6%; 93.4%; 76.2%; 85.6%). A total 13 482 patients, with first hospital, were included 678; 4060; 485; 8321). Of these, <50% after year 41.3%; 22.1%; 22.4%; 41.8%). Conclusion This work shows that diagnoses conditions examined recorded ≤30 days, making possible. The pattern condition-specific could be adjust analysis. Despite low sensitivity recording, implementing worthwhile carried out, at least on trial basis, interest. © 2017 Authors. Pharmacoepidemiology & Drug Safety Published John Wiley Sons Ltd.