Interest of the trajectory method for the evaluation of outcomes after in utero drug exposure: example of anxiolytics and hypnotics

• DOI: 10.1002/pds.4199
• Publication Date: 2017-03-24T12:00:13Z
• Authors: Caroline Hurault‐...; Cécile Chouquet; Nicolas Savy; Isabelle Lacroix; Anna‐Belle Beau; Jean‐Louis Montas...; Christine Damase‐...
• Keywords: Adult; Male; Pharmacoepidemiology; Infant, Newborn; Infant, Newborn, Diseases; 3. Good health; Pregnancy Complications; 03 medical and health sciences; 0302 clinical medicine; Anti-Anxiety Agents; [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST]; Pregnancy; Prenatal Exposure Delayed Effects; Humans; Hypnotics and Sedatives; Female

Abstract Purpose The aim of this study was to examine the potential benefit take into account duration and intensity drug exposure using recently published method based on individual trajectories. This approach used define profiles anxiolytics/hypnotics during pregnancy evaluate effect newborn health. Methods performed in EFEMERIS database (54 918 mother–children pairs). An estimation adaptation extrauterine life assessed several criteria especially cardio‐respiratory symptoms. A proxy variable called “neonatal pathology” created. occurrence event studied two approaches: Standard Method comparing exposed unexposed newborns, Trajectory different exposure. Results Around 5% newborns ( n = 2768) were identified be anxiolytics or hypnotics pregnancy. Using Method, 6.2% developed a against 4.8% (odds ratios [OR] 0.9[0.8–1.2], p 0.7). With taking evolution treatment intensity, four pregnant women identified. significant difference rates pathologies” observed between 0.0002). Newborns utero high constant level more at risk developing than (OR 1 2.0 [1.0–3.9] OR 2 7.6 [2.8–20.5]). Conclusions present demonstrates interest trajectories for evaluation outcomes pharmaco‐epidemiological studies specifically Copyright © 2017 John Wiley & Sons, Ltd.