Impact of Ketamine Use on Adjunctive Analgesic and Sedative Medications in Critically Ill Trauma Patients

• DOI: 10.1002/phar.2042
• Publication Date: 2017-10-11T01:36:37Z
• Authors: Kaitlin A. Prusko...; Kelly Harbourt; Mehrnaz Pajoumand; Sai‐Ho Jason Chui; H. Neal Reynolds
• Keywords: Dexmedetomidine

Ketamine may be used to manage pain and agitation that is refractory what are usually considered traditional agents such as fentanyl, propofol, benzodiazepines, dexmedetomidine; however, literature describing the use of ketamine continuous infusions for this purpose in critically ill trauma patients limited.The primary objective study was determine impact initiation a infusion on sedative analgesic patients. Secondary objectives were identify patient population which initiated, assess proportion time at their goal level sedation, dosing patterns adjunctive agents.This single-center retrospective chart review over 19-month period included mechanically ventilated adult whom initiated management sedation agitation. Patients who received other indications or by acute service not evaluation.Thirty-six study. tended white men with blunt trauma. Overall, associated decrease amount opioids propofol an increase ziprasidone dexmedetomidine needed achieve Richmond Agitation Sedation Score. When compared before initiation, achieved significantly different after addition ketamine.Although decreased opioid use, it also increased maintain sedation. Further examination clinical outcomes these differences drug larger warranted routine analgesia can recommended.