Extracellular matrix regenerated: tissue engineering via electrospun biomimetic nanofibers

• DOI: 10.1002/pi.2344
• Publication Date: 2007-09-10T18:16:57Z
• Authors: Scott Sell; Catherine Barnes; Matthew Smith; Michael McClure; Parthasarathy Mad...; Joshua Grant; Michael McManus; Gary Bowlin
• Keywords: Electrospinning; Polycaprolactone

Abstract While electrospinning had seen intermittent use in the textile industry from early twentieth century, it took explosion of field tissue engineering, and its pursuit biomimetic extracellular matrix (ECM) structures, to create an renaissance. Over past decade, a growing number researchers engineering community have embraced as polymer processing technique that effectively routinely produces non‐woven structures nanoscale fibers (sizes 80 nm 1.5 µm). These nanofibers are physiological significance they closely resemble structure size scale native ECM (fiber diameters 50 500 nm). Attempts replicate many roles led wide array polymers, both synthetic (poly(glycolic acid), poly(lactic polydioxanone, polycaprolactone, etc.) natural (collagen, fibrinogen, elastin, origin, for multitude different applications. With various compositions, fiber dimensions orientations, biological, chemical mechanical properties electrospun materials can be tailored. In this review we highlight role tissues applications (skin/wound healing, cartilage, bone, vascular tissue, urological tissues, nerve, ligament), discuss potential future work. Copyright © 2007 Society Chemical Industry