Breast Cancer‐Derived Exosomes Reflect the Cell‐of‐Origin Phenotype

• DOI: 10.1002/pmic.201800180
• Publication Date: 2019-01-24T09:49:48Z
• Authors: Shu Wen Wen; Luize G. Lima; Richard J. Lobb; Emma L. Norris; Marcus L. Hastie; Sophie Krumeich; Andreas Möller
• Keywords: Exosome; Cell type

Abstract A manner in which cells can communicate with each other is via secreted nanoparticles termed exosomes. These vesicles contain lipids, nucleic acids, and proteins, are said to reflect the cell‐of‐origin. However, for exosomal protein content, there limited evidence literature verify this statement. Here, proteomic assessment combined pathway‐enrichment analysis used demonstrate that cargo of exosomes reflects epithelial/mesenchymal phenotype secreting breast cancer cells. Given epithelial‐mesenchymal plasticity known implicate various stages progression, results suggest subtypes distinct epithelial mesenchymal phenotypes may be distinguished by directly assessing content Additionally, work a substantial step toward verifying statement cell‐derived cells‐of‐origin.