Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

• DOI: 10.1002/pmic.202400317
• Publication Date: 2025-04-11T05:50:01Z
• Authors: Luca Musella; Jens Möller; Christopher Lischer; Julio Vera‐Gonzalez; Jörg Hofmann; Lisa Ott; Andreas Burkovski
• Keywords: Corynebacterium diphtheriae; Proteome; Phagolysosome; Internalization

ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light the simultaneous intracellular adaptation bacteria changes in proteome phagocytes response internalization C. . Quantitative analyses were carried out at different time points an infection assay data analyzed by bioinformatic approaches. Several proteins, which not observed or connected pathogenicity before, differentially expressed, as well key macrophage components phagolysosome. Overall, responded phagocytosis DNA repair, transcription, cell wall synthesis while showed innate immune system.