Psychological functioning in persons considering genetic counseling and testing for Li–Fraumeni syndrome

• DOI: 10.1002/pon.1352
• Publication Date: 2008-08-07T15:09:35Z
• Authors: Susan K. Peterson; Rebecca D. Pentz; Salma K. Marani; Patricia A. Ward; Amie M. Blanco; Denise LaRue; Kristen Vogel; Tamara Solomon; Louise C. Strong
• Keywords: Worry; Li–Fraumeni syndrome

Abstract Objective : Li–Fraumeni syndrome (LFS) confers an increased risk of multiple types cancer in both children and adults. Clinical genetic testing for deleterious germline p53 gene mutations can identify most LFS‐affected families. We evaluated factors associated with cancer‐specific distress perceived self‐efficacy coping a positive test result among persons at having mutations. Methods One hundred thirty‐five from 15 families were invited to take part study that offered counseling complete psychosocial measures. Results Participants ( n =92) more likely be younger female than nonparticipants =43). In multivariate analyses, greater was lower quality life, higher mutation, no personal history number first degree relatives (FDRs) affected cancer. Lower worry, decisional conflict about Conclusions Individual perceptions testing, as well experience FDRs' diagnoses deaths, should addressed during the process Copyright © 2008 John Wiley & Sons, Ltd.