Plasma Modification of PCL Porous Scaffolds Fabricated by Solvent‐Casting/Particulate‐Leaching for Tissue Engineering

• DOI: 10.1002/ppap.201300149
• Publication Date: 2014-01-07T08:31:03Z
• Authors: Francesca Intranuovo; Roberto Gristina; Francesco Brun; Sara Mohammadi; Giacomo Ceccone; Eloisa Sardella; François Rossi; Giuliana Tromba; Pietro Favia
• Keywords: chemical gradient; hydrophilicity; plasma deposition; porosity; scaffold; porosity; 02 engineering and technology; hydrophilicity; scaffold; 0210 nano-technology; chemical gradient; plasma deposition

AbstractThe improvement of scaffold performances as cell carriers in a tissue implant is still a challenge in tissue engineering. Since cells in contact with a scaffold firstly sense its top surface before interacting with its macro‐/micro‐porous structure, the insertion of chemical motifs within the body of the scaffold could improve cell colonization through its entire structure. In this study, combinations of plasma deposition and treatment processes have been employed to create chemical gradients inside polycaprolactone porous scaffolds, whose micro‐morphology has been finely characterized with synchrotron radiation computed micro‐tomography. The graded chemical composition of these scaffolds has successfully allowed the increase of cell viability with respect to untreated materials.