Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: A phase I feasibility study

• DOI: 10.1002/ppul.10290
• Publication Date: 2003-05-09T10:08:01Z
• Authors: Hans Kollberg; David Carlander; Hanne Olesen; Per‐Erik Wejåker; Marie Johannesson; Anders Larsson
• Keywords: Sputum culture

Respiratory infection is the major cause of morbidity and mortality in cystic fibrosis (CF) patients. Chronic Pseudomonas aeruginosa (PA) infections ultimately occur virtually all It impossible to eradicate PA when a patient has been chronically colonized. Immunotherapy with specific egg-yolk antibodies (IgY) may be an alternative antibiotics for prevention infections. We wanted determine if treatment IgY can prolong period between first second colonization? And long-term, diminish number positive cultures postpone onset chronic CF patients gargled daily IgY-antibody preparation, purified from eggs hens immunized bacteria. They were compared group who did not gargle preparation. Both groups had their colonization eradicated by antibiotics. The basic was essentially same both groups. In initial study, significantly prolonged treated vs. control (Kaplan-Meier P = 0.015, Breslow test). only 2.5 sputum per 100 months observation, none these became colonized PA. No adverse events reported. group, 13.7 observation PA, 5 (24%) This feasibility study shows that antipseudomonal potential effectively prevent without any severe effects. A phase III should initiated.