Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5

• DOI: 10.1002/ppul.20597
• Publication Date: 2007-04-11T16:59:52Z
• Authors: M.L. García‐García; C. Calvo; I. Casas; T. Bracamonte; A. Rellán; F. Gozalo; T. Tenorio; P. Pérez‐Breña
• Keywords: Atopy

Abstract Background Human metapneumovirus (hMPV) infection plays an important role in the pediatric respiratory infections. However, little is known about relationship between hMPV‐bronchiolitis and development of subsequent wheezing. The aim this study was to evaluate outcome at third fifth year after admission for compare it with children admitted syncytial virus (RSV)‐bronchiolitis without lower disease first 2 years life. Methods We studied 55 (23 hMPV 32 RSV acute bronchiolitis) aged 3–5 hospitalized during seasons 2000–2005. Thirty‐eight due rotavirus gastroenteritis same seasons, bronchiolitis infancy, were also analyzed. Clinical data collected through structured clinical interviews follow‐up visit. Skin prick tests food inhaled allergens performed. Results Asthma significantly more frequent (odds ratio (OR) = 5.21), RSV‐bronchiolitis (OR 4.68), allergic rhinitis 1.7), siblings atopy 1.75). In multivariate analyses, most risk factor asthma preschool 15.9), followed by 10.1) 4.9). No differences found respect rhinitis, atopic dermatitis, allergy, proportion positive tests, family history atopy, asthma. Conclusions infancy strongly associated as well other forms bronchial obstructive This association is, least, strong observed Pediatr Pulmonol. 2007; 42:458–464. © 2007 Wiley‐Liss, Inc.