The impact of reflux burden on Pseudomonas positivity in children with Cystic Fibrosis

• DOI: 10.1002/ppul.21598
• Publication Date: 2011-12-07T21:47:17Z
• Authors: Kara Palm; Gregory Sawicki; Rachel Rosen
• Keywords: Lung Diseases; Esophageal pH Monitoring; Adolescent; Cystic Fibrosis; Proton Pump Inhibitors; Hydrogen-Ion Concentration; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Forced Expiratory Volume; Pseudomonas aeruginosa; Gastroesophageal Reflux; Humans; Pseudomonas Infections; Child; Lung; Retrospective Studies

Abstract Objectives Nonacid gastroesophageal reflux (GER), particularly in patients taking acid suppression, has been implicated as a cause of respiratory infections. We hypothesize that children with cystic fibrosis (CF) and higher nonacid burden have greater rates Pseudomonas aeruginosa (Pa) infection than lower burden. Study Design reviewed the multichannel intraluminal impedance (pH‐MII) tracings 35 CF between 2003 2010. compared profiles those who were Pa positive negative. Results The mean age was 13.5 ± 5.8 years. Twenty‐seven (76%) positive. Ninety seven percent proton pump inhibitors during pH‐MII testing. percentage time pH <4 8.5 12%. had significantly total, proximal ( P < 0.009). There negative correlation FEV1 (r = −0.397, 0.03) total number events −0.474, After adjusting for FEV1, remains associated positivity 0.055). Conclusions Increased may predispose to worse lung function. Pediatr Pulmonol. 2012; 47:582–587. © 2011 Wiley Periodicals, Inc.