The utility of glucose area under the curve from the oral glucose tolerance test as a screening tool for cystic fibrosis‐related diabetes

• DOI: 10.1002/ppul.26100
• Publication Date: 2022-08-24T01:28:09Z
• Authors: Alex Gileles‐Hillel; Liora H. Soesman; Silwan Miari; Oded Breuer; Reuven Tsabari; Hila Elyashar‐Earon; Shoshana Armoni; Aline B. Sprikkelman; Joel Reiter; David Zangen; Eran Lavi; Eitan Kerem; Malena Cohen‐Cymb...
• Keywords: Cystic fibrosis-related diabetes; Glucose tolerance test

Consistently abnormal glucose levels on oral tolerance test (OGTT) are the most effective screening tool for cystic fibrosis-related diabetes (CFRD). However, some fibrosis (CF) patients demonstrate profiles not reaching required CFRD diagnosis and are, therefore, left untreated. Since is associated with disease deterioration, early treatment desirable.To explore association between area under curve of (G-AUC) obtained during a five-point 2-h standard OGTT CF severity parameters.All referred an annual routine at Hadassah Center 2002 2018, were included. Disease parameters correlated G-AUC.Two hundred forty-two OGTTs performed in 81 (mean age 19.7 ± 9.0 years); 54% normal, 14% showed impaired (IGT), 5% had values indeterminate range (INDET), 11% both IGT INDET 16% diagnosed CFRD. A gradual increase mean G-AUC was observed among groups. In multivariate regression models, ≥ 295 mg h/dl independently increased number pulmonary exacerbations (PEx). Not all having this value met definition.Patients who do fulfill criteria may have metabolism identifiable by abnormally high values, which be more PEx. The potential advantage treating these insulin subsequent reduction PEx needs further investigation.