Rosetta in CASP4: Progress in ab initio protein structure prediction

• DOI: 10.1002/prot.1170
• Publication Date: 2002-08-25T22:17:27Z
• Authors: Richard Bonneau; Jerry Tsai; Ingo Ruczinski; Dylan Chivian; Carol Rohl; Charlie E. M. Str...; David Baker
• Keywords: Sequence (biology)

Rosetta ab initio protein structure predictions in CASP4 were considerably more consistent and accurate than previous predictions. Large segments correctly predicted (>50 residues superimposed within an RMSD of 6.5 Å) for 16 the 21 domains under 300 which models submitted. Models with global fold largely correct produced several targets new folds, difficult recognition targets, those traditional models. These promising results suggest that may soon be able to contribute interpretation genome sequence information. Proteins 2001;Suppl 5:119–126. © 2002 Wiley-Liss, Inc.