Towards computing with proteins

• DOI: 10.1002/prot.20886
• Publication Date: 2006-01-24T22:05:01Z
• Authors: Ron Unger; John Moult
• Keywords: DNA Computing; Robustness; Biological data

Can proteins be used as computational devices to address difficult problems? In recent years there has been much interest in biological computing, that is, building a general purpose computer from molecules. Most of the current efforts are based on DNA because its ability self-hybridize. The exquisite selectivity and specificity complex protein-based networks motivated us suggest similar principles can devise systems will able directly implement any logical circuit parallel asynchronous computation. Such devices, powered by ATP molecules, would perform, for medical applications, digital computation with natural interface input conditions. We discuss how design protein molecules serve basic element functioning NAND gate, utilizing tags recognition, phosphorylation exonuclease reactions information processing. A solution these elements could carry out effective Finally, model robustness errors were tested simulation.