Critical assessment of methods of protein structure prediction (CASP)—Round XIV

• DOI: 10.1002/prot.26237
• Publication Date: 2021-09-17T14:30:27Z
• Authors: Andriy Kryshtafovych; Torsten Schwede; Maya Topf; Krzysztof Fidelis; John Moult
• Keywords: CASP

Critical assessment of structure prediction (CASP) is a community experiment to advance methods computing three-dimensional protein from amino acid sequence. Core components are rigorous blind testing and evaluation the results by independent assessors. In most recent (CASP14), deep-learning one research group consistently delivered computed structures rivaling corresponding experimental ones in accuracy. this sense, represent solution classical protein-folding problem, at least for single proteins. The models have already been shown be capable providing solutions problematic crystal structures, there broad implications rest structural biology. Other groups also substantially improved performance. Here, we describe these outline some many implications. related areas CASP, including modeling complexes, refinement, estimation model accuracy, inter-residue contacts distances, described.