Thermal hazard investigation of a pharmaceutical intermediate

• DOI: 10.1002/prs.11917
• Publication Date: 2017-08-12T04:02:44Z
• Authors: Ralph Zhao; Dan Muzzio; Tom Vickery; Elizabeth Fisher; Laura Artino; Jay Yin; Joe Hinksmon; Adam Fine
• Keywords: Process Safety; Anhydrous; Thermal Stability; Thermal instability

During the process development of a pharmaceutical advanced intermediate, new chemistry using an aqueous workup resulted in discovery hydrated crystal form this intermediate. This showed thermal instability at relatively low temperature compared to original anhydrous form. Thermal stability and associated safety hazards were investigated order ensure transportation © 2017 American Institute Chemical Engineers Process Saf Prog 37: 263–267, 2018