Biological activities of Prunella vulgaris extract

• DOI: 10.1002/ptr.1324
• Publication Date: 2003-10-28T08:01:35Z
• Authors: Jitka Psotová; Milan Kolář; Jaromír Soušek; Zdeněk Švagera; Jaroslav Vičar; Jitka Ulrichová
• Keywords: Rosmarinic acid; Prunella vulgaris; HaCaT; Haemolysis

Abstract The organic fraction (OF; 25.7% w/w of rosmarinic acid) Prunella vulgaris (total extract) was found to exhibit the following: scavenging activity on diphenylpicrylhydrazyl radical (DPPH), inhibition in vitro human LDL Cu(II)‐mediated oxidation, protection rat mitochondria and hepatocytes exposed either tert ‐butyl hydroperoxide, or Cu(II) Fe(III) ions. OF also showed a potential inhibit erythrocyte haemolysis it reduced production LTB 4 bovine PMNL generated by 5‐lipoxygenase pathway. Other observations included antiproliferative effects against HaCaT cells mouse epidermal fibroblasts moderate antimicrobial gram‐positive bacteria. Rosmarinic, caffeic 3‐(3,4‐dihydroxyphenyl)lactic acids exhibited less potent than plant extract all bioassays. antioxidative, antimicrobial, together with antiviral offer good prospects for medicinal applications P. . Copyright © 2003 John Wiley & Sons, Ltd.