In vitro antimycotic activity of some plant extracts towards yeast and yeast‐like strains

• DOI: 10.1002/ptr.1622
• Publication Date: 2005-03-30T09:47:06Z
• Authors: B. Turchetti; P. Pinelli; P. Buzzini; A. Romani; D. Heimler; F. Franconi; A. Martini
• Keywords: Candida glabrata

Abstract As part of screening aimed at the selection novel antimycotic compounds vegetable origin, leaf extracts Camellia sinensis L., Cupressus sempervirens L. and Pistacia lentiscus seed extract Glycine soja Sieb. et Zucc. were tested against yeast yeast‐like species implicated in human mycoses. Of only those C. (obtained from a commercial preparation green tea) exhibited broad activity towards Candida glabrata , Clavispora lusitatiae Cryptococcus laurentii Filobasidiella neoformans Issatchenkia orientalis Saccharomyces cerevisiae Prototheca wickerhamii strains. MICs ranging 300 to 4800 µg extract[sol ]mL (corresponding 130–2010 µg[sol total polyphenols) observed. Concentrations over 25 000 caused rapid decrease viable cells Fil. its was dose‐dependent. Tests carried out using pure polyphenols present composition, showed that epicatechin‐3‐O‐gallate (ECG) epigallocatechin‐3‐O‐gallate (EGCG) possess activity. Copyright © 2005 John Wiley & Sons, Ltd.