Kushenflavonoids induce apoptosis in tumor cells by inhibition of NF‐κB activation and multiple receptor tyrosine kinase activities

• DOI: 10.1002/ptr.2065
• Publication Date: 2006-12-21T14:47:55Z
• Authors: Jun Han; Mingyu Sun; Yumin Cui; Tao Wang; Weihan Zhang; Mingchuan Guo; Yuan Zhou; Wei Liu; Meifang Zhang; Jifeng Duan; Sidong Xiong; Minghui Yao; Xiaoqiang Yan
• Keywords: A431 cells

In this report, the mechanism of antitumor activities Kushen flavonoids (KS-Fs) were explored. KS-Fs and kurarinone (Kur), a single flavonoid compound, able to induce apoptosis H460 Eca-109 cells in vitro vivo. The inducing effect was enhanced presence Taxol. xenograft mice treated with Kur, down-regulation Bcl-2 up-regulation caspase 8 3 tumors observed by immunohistochemical staining. addition, Kur inhibit TNFalpha-induced NF-kappaB activation 293 mediated decreased IkappaBalpha phosphorylation. Further effects on multiple receptor tyrosine kinase cell-based assays, inhibited EGF-induced EGF phosphorylation A431 constitutively activated Her-2 MDA-MB-453s cells. enzymatic KDR, but not PDGF BR activities. an inhibition observed. These results reveal novel which induces acting cellular targets including