Antiinflammatory effect of topically applied propolis extract in carrageenan‐induced rat hind paw edema

Male 0303 health sciences Neutrophils Administration, Topical Chemotaxis Anti-Inflammatory Agents Carrageenan Propolis Rats 3. Good health Rats, Sprague-Dawley 03 medical and health sciences Animals Edema Humans Cells, Cultured
DOI: 10.1002/ptr.2093 Publication Date: 2007-02-02T19:04:45Z
ABSTRACT
AbstractThe antiinflammatory effect of an ointment containing propolis extract (3%–7%) was examined using carrageenan‐induced hind paw edema in rats. Treatment with the ointment inhibited the edema moderately, and the inhibition was significant at 5% and 7%. Additionally, the effect of the ointment on chemotaxis of human polymorphonuclear leukocytes (PMNs) was investigated using the agarose plate method. Migration of PMNs toward zymosan‐treated serum was inhibited in the presence of 5% propolis ointment. These results demonstrate that topical application of propolis extract is effective in inhibiting carrageenan‐induced rat hind paw edema, and its inhibitory effect on the chemotaxis of PMNs may also contribute to the antiinflammatory effect. Copyright © 2007 John Wiley & Sons, Ltd.
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