Antiinflammatory effect of topically applied propolis extract in carrageenan‐induced rat hind paw edema

• DOI: 10.1002/ptr.2093
• Publication Date: 2007-02-02T19:04:45Z
• Authors: Yukiko Naito; Misao Yasumuro; Keiichiro Kondou; Naoki Ohara
• Keywords: Propolis; Carrageenan; Zymosan; Hindlimb

Abstract The antiinflammatory effect of an ointment containing propolis extract (3%–7%) was examined using carrageenan‐induced hind paw edema in rats. Treatment with the inhibited moderately, and inhibition significant at 5% 7%. Additionally, on chemotaxis human polymorphonuclear leukocytes (PMNs) investigated agarose plate method. Migration PMNs toward zymosan‐treated serum presence ointment. These results demonstrate that topical application is effective inhibiting rat edema, its inhibitory may also contribute to effect. Copyright © 2007 John Wiley & Sons, Ltd.