Protective effect of Lycium barbarum on doxorubicin‐induced cardiotoxicity

• DOI: 10.1002/ptr.2186
• Publication Date: 2007-07-11T11:16:29Z
• Authors: Yan‐Fei Xin; Guo‐Liang Zhou; Zu‐Yue Deng; Yun‐Xiang Chen; Yue‐Guo Wu; Pan‐Sheng Xu; Yao‐Xian Xuan
• Keywords: Lycium; Cardiotoxicity

Abstract The objective of this work was to explore the hypothesis that Lycium barbarum (LB) may be protective against doxorubicin (DOX)‐induced cardiotoxicity through antioxidant‐mediated mechanisms. Male SD rats were treated with distilled water or a extract LB (25 mg/kg, p.o.) daily and saline DOX (5 i.v.) weekly for 3 weeks. Mortality, general condition body weight observed during experiment. DOX‐induced assessed by electrocardiograph, heart antioxidant activity, serum levels creatine kinase (CK) aspartate aminotransferase (AST) histopathological change. group showed higher mortality (38%) worse physical characterization. Moreover, caused myocardial injury manifested arrhythmias conduction abnormalities in ECG (increased QT ST intervals elevation), decrease an increase CK AST, as well lesions. Pretreatment significantly prevented loss myofibrils improved function DOX‐treated evidenced from lower (13%), normalization antioxidative activity AST CK, improving abnormalities. These results suggested elicited typical cardioprotective effect on DOX‐related oxidative stress. Furthermore, vitro cytotoxic study antitumor not compromised LB. It is possible could used useful adjunct combination chemotherapy. Copyright © 2007 John Wiley & Sons, Ltd.