Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus‐castus

• DOI: 10.1002/ptr.2492
• Publication Date: 2009-05-13T14:36:37Z
• Authors: M. Ahmed Mesaik; Azizuddin; Shahnaz Murad; Khalid Mohammed Khan; Rasool Bakhsh Tareen; Aqeel Ahmed; Atta‐ur‐Rahman; Muhammad Iqbal Ch...
• Keywords: Monocyte

Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus-castus, was found to be potent immunomodulatory and cytotoxic compound. The activity tested in vitro for chemiluminescence, chemotaxis, T-cell proliferation cytotoxicity. (1) exhibited significant inhibitory effect on monocyte oxidative burst dose dependent manner. It have suppressive chemotaxic action at higher concentrations fMLP (10(-8) m) stimulated neutrophils. also showed PHA (PMBC).