Effect of aqueous extract of Adenia cissampeloides on blood pressure and serum analytes of hypertensive patients

• DOI: 10.1002/ptr.2650040107
• Publication Date: 2006-10-18T04:14:51Z
• Authors: Alex A. Nyarko; Marian E. Addy
• Keywords: Nephrotoxicity; Creatine kinase; Blood urea nitrogen; Creatine

Abstract Seven female hypertensive subjects, being treated with an aqueous extract of Adenia cissampeloides , (‘Adenia’), and seven weight‐, age‐ sex‐matched subjects about to begin treatment, were used evaluate the therapeutic possible toxic effects this herbal preparation which is at Centre for Scientific Research into Plant Medicine (CSRPM), control hypertension. Measurements systolic diastolic blood pressures recorded, serum levels α‐hydroxybutyrate dehydrogenase (HBDH), aspartate aminotransferase (AST), lactate (LDH) creatine kinase (CK) determined give indication effectiveness ‘Adenia’ as anti‐hypertensive agent. Serum γ‐glutamyl transferase (GGT), alanine (ALT), alkaline phosphatase (ALP), bilirubin, proteins cholesterol indicate liver damage, urea nitrogen (BUN), creatinine clearance rate assessment nephrotoxicity. Systolic pressure was significantly lower in on compared not ‘Adenia’. (p <0.01). HBDH CK, patients ‘Adenia’, but differences statistically significant. Levels total conjugated bilirubin (P < 0.05). The plant appears have hepatotoxic or nephrotoxic effects.