Inhibitory effects of indonesian plant extracts on reverse transcriptase of an RNA Tumour Virus (I)

• DOI: 10.1002/ptr.2650060504
• Publication Date: 2006-10-18T04:41:35Z
• Authors: I. T. Kusumoto; I. Shimada; N. Kakiuchi; M. Hattori; T. Namba; S. Supriyatna
• Keywords: 0303 health sciences; 03 medical and health sciences; 3. Good health

Abstract Methanol and water extracts of 30 Indonesian medicinal plants were tested for inhibitory activity on avian myeloblastosis virus (AMV)‐reverse transcriptase (RT). The most potent inhibition was shown by Loranthus parasiticus (whole plant), Helicteres isora (fruit), Terminalia belerica (fruit peel), Strobilanthes crispus (leaves) Woodfordia floribunda (flower leaves). Two kinds template‐primers, (rA) n ‐(dT) 12–18 (rC) ‐(dG) examined polymerization reaction but the stronger in directed samples. These showed no appreciable cytotoxicity at concentrations where over 90% RT inhibited.