Impact of the preparation process on immunomodulatory activities of the ayurvedic drug Nimba arishta

• DOI: 10.1002/ptr.2650070110
• Publication Date: 2006-10-18T04:48:51Z
• Authors: B. H. Kroes; A. J. J. Van Den ...; R. P. Labadie; A. M. Abeysekera; K. T. D. De Silva
• Keywords: Azadirachta; Ingredient; Decoction; Pharmacopoeia

Abstract Nimba arishta is an ayurvedic drug obtained by fermentation of a decoction Azadirachta indica bark to which sugar and kalka have been added. Kalkas consist various plant materials including flowers Woodfordia fruticosa . The effects the preparation process on immunomodulatory properties were investigated means model systems. On basis traditional applications arista in Sri Lanka, complement activity functioning granulocytes selected as relevant immunological parameters our studies. Long boiling times, consequence commercial scale, found substantially reduce activities, whereas addition resulted marked increase. Inoculation with yeasts ( Saccharomyces cerevisiae or Schizosaccharomyces pombe var. ) microorganisms introduced through did not affect vitro activities Further investigations revealed that ingredient most pronounced biological activities. Although quantitative terms strongly dominates preparation, it was shown detailed studies represent major respect modulation activity.