Cardioprotective potential of myricetin in isoproterenol‐induced myocardial infarction in wistar rats

• DOI: 10.1002/ptr.2688
• Publication Date: 2009-03-23T08:59:07Z
• Authors: Roshan Tiwari; Mahalaxmi Mohan; Sanjay Kasture; Andrea Maxia; Mauro Ballero
• Keywords: Myricetin; Creatine kinase; Cardiac marker; Isoprenaline

Abstract The study aimed to evaluate the protective role of myricetin obtained from Vitis vinifera (Vitaceae) on heart rate, electrocardiographic (ECG) patterns, vascular reactivity catecholamines, cardiac marker enzymes, antioxidant enzymes together with morphological and histopathological changes in isoproterenol (ISO) induced myocardial infarction (MI) male Wistar rats. Rats treated (85 mg/kg, administered subcutaneously twice at an interval 24 h) showed a significant increase rate ST elevation ECG, levels – lactate dehydrogenase (LDH), creatine kinase (CK) aspartate aminotransferase (AST) serum. Isoproterenol significantly reduced superoxide dismutase (SOD) catalase (CAT) activity increased various catecholamines. Pretreatment (100 p.o. 300 p.o.) for period 21 days inhibited effects ISO LDH, CK, AST, SOD, CAT, ECG patterns. Treatment mg/kg mg/kg) alone did not alter any parameters compared vehicle Myricetin animals lesser degree cellular infiltration studies. Thus, ameliorates cardiotoxic may be value treatment MI. Copyright © 2009 John Wiley & Sons, Ltd.