Screening of selected food and medicinal plant extracts for pancreatic lipase inhibition

• DOI: 10.1002/ptr.2718
• Publication Date: 2008-12-23T12:17:20Z
• Authors: Petra Slanc; Bojan Doljak; Samo Kreft; Mojca Lunder; Damjan Janeš; Borut Štrukelj
• Keywords: Lipid digestion; Nutraceutical; Functional food

Abstract Lipids are important components in human nutrition; however, their increased intake contributes to the development of obesity and can lead multiple long‐term complications. Pancreatic lipase (triacylglycerol acylhydrolase, EC 3.1.1.3) is a key enzyme for absorption dietary triglycerides. Interference with fat hydrolysis results reduced utilization ingested lipids, therefore inhibition lipases decreases absorption. Extracts from 106 species medicinal plants, vegetables fruits were screened potential inhibitory activity. p ‐Nitrophenylpalmitate 5‐bromo‐4‐chloro‐3‐indoxylpalmitate used as substrates an vitro test crude porcine pancreatic lipase. Bearberry ( Arctostaphylos uva‐ursi ), garden pea Pisum sativum Norway spruce Picea abies ) large‐leaved lime Tilia platyphyllos extracts most active. Additionally, activity selected removed polyphenols was measured. bearberry, promising source developing functional foods or isolating active compounds. Copyright © 2008 John Wiley & Sons, Ltd.