Memory performance, brain excitatory amino acid and acetylcholinesterase activity of chronically aluminum exposed mice in response to soy isoflavones treatment

• DOI: 10.1002/ptr.3120
• Publication Date: 2010-05-17T15:46:04Z
• Authors: Yan‐qiang Liu; Tian‐rong Xin; Jing‐jing Liang; Wei‐ming Wang; Yuan‐yuan Zhang
• Keywords: Glutamic acid; Aspartic acid

Memory performance, brain excitatory amino acid and acetylcholinesterase activity of chronically aluminum (Al) exposed mice in response to soy isoflavones (SI) treatment was investigated the study. Forty eight were allotted randomly into a control group, an Al group (100 mg/kg Al) treated with SI + 60 SI) for days. Chronic exposure significantly impaired long memory performance as assessed using passive avoidance task test (χ(2) analysis, p < 0.05). Interestingly, markedly improved score mice. This improvement associated total reversal Al-induced increases cerebral cortex hippocampus The also led significant decreases levels aspartic glutamic acids, two neurotransmitters; whereas partially reversed decreased contents hippocampus. results suggest that can improve mice, possibly by modulating metabolism acetylcholine neurotransmitters.