Lipid‐soluble Extracts from Salvia miltiorrhiza Inhibit Production of LPS‐induced Inflammatory Mediators via NF‐κB Modulation in RAW 264.7 Cells and Perform Antiinflammatory Effects In Vivo

• DOI: 10.1002/ptr.3680
• Publication Date: 2012-01-07T04:28:39Z
• Authors: Meng Li; Lei Zhang; Run‐Lan Cai; Yuan Gao; Yun Qi
• Keywords: Salvia miltiorrhiza; IκBα

Salvia miltiorrhiza, a traditional Chinese herbal medicine, is used to treat various inflammatory diseases. In the present study, antiinflammatory effects of S. miltiorrhiza lipid-soluble extracts (SMLE) were demonstrated in vitro and vivo, along with its underlying mechanism action. SMLE significantly inhibited production NO, TNF-α, IL-1β IL-6 lipopolysaccharides (LPS)-stimulated RAW 264.7 cells. also LPS-induced degradation IκB-α cytoplasm translocation p65 nucleus addition, intracellular reactive oxygen species (ROS) surface expression CD14 induced by LPS. animal models, intraperitoneal administration increased survival rate endotoxemia sepsis mice. The topical ear edema PMA. It was found that inhibits gene protein iNOS, macrophages blocking NF-κB activation, these are mediated, at least part, through inhibition ROS generation CD14. results suggest possible therapeutic application diseases provide scientific evidence support medical practice treatment miltiorrhiza.