Mangosenone F, A Furanoxanthone from Garciana mangostana, Induces Reactive Oxygen Species‐Mediated Apoptosis in Lung Cancer Cells and Decreases Xenograft Tumor Growth

• DOI: 10.1002/ptr.5428
• Publication Date: 2015-08-27T10:55:49Z
• Authors: Kyung Hye Seo; Hyung Won Ryu; Mi Jin Park; Ki Hun Park; Jin Hyo Kim; Mi‐Ja Lee; Hyeon Jung Kang; Sun Lim Kim; Jin Hwan Lee; Woo Duck Seo
• Keywords: 0303 health sciences; Lung Neoplasms; Xanthones; Cytochromes c; Mice, Nude; Antineoplastic Agents; Apoptosis; 3. Good health; Garcinia mangostana; Mitochondria; Mice; 03 medical and health sciences; Caspases; Cell Line, Tumor; Animals; Heterografts; Humans; Cisplatin; Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction

Mangosenone F (MSF), a natural xanthone, was isolated form Carcinia mangotana, and a few studies have reported its glycosidase inhibitor effect. In this study we investigated the anti lung cancer effect of MSF both in vitro and in vivo. MSF inhibited cancer cell cytotoxicity and induced and induced apoptosis via reactive oxygen species (ROS) generation in NCI‐H460. MSF treatment also showed in pronounced release of apoptogenic cytochrome c from the mitochondria to the cytosol, downregulation of Bcl‐2 and Bcl‐xL, and upregulation of Bax, suggesting that caspase‐mediated pathways were involved in MSF‐induced apoptosis. ROS activation of the mitogen‐activated protein kinase signaling pathway was shown to play a predominant role in the apoptosis mechanism of MSF. Compared with cisplatin treatment, MSF treatment showed significantly increased inhibition of the growth of NCI‐H460 cells xenografted in nude mice. Together, these results indicate the potential of MSF as a candidate natural anticancer drug by promoting ROS production. Copyright © 2015 John Wiley & Sons, Ltd.