Anti-inflammatory Activity of Constituents Isolated from Aerial Part of Angelica acutiloba Kitagawa

• DOI: 10.1002/ptr.5490
• Publication Date: 2015-10-14T07:19:49Z
• Authors: Takuhiro Uto; Nguyen Huu Tung; Risa Taniyama; Tosihide Miyanowaki; Osamu Morinaga; Yukihiro Shoyama
• Keywords: Kampo; Phthalide; Phytochemical; Anti-inflammatory

Recently, the resources of medicinal plants have been exhausting. The root Angelica acutiloba is one most important ingredients in Japanese Kampo medicine for treatment gynecological diseases. In our search alternative plant A. acutiloba, we found that its aerial part has anti-inflammatory potency as well root. Phytochemical investigation resulted isolation four compounds including a new dimeric phthalide, namely tokiaerialide (2), along with Z-ligustilide (1), falcarindiol (3), and bergaptol (4). Next, investigated vitro activity 1–4 lipopolysaccharide-stimulated RAW264 macrophages. Among isolated compounds, 1 exhibited potent inhibition against lipopolysaccharide-induced production prostaglandin E2, nitric oxide, pro-inflammatory cytokines (interleukin-6 tumor necrosis factor-α). Compounds 3 4 also inhibited all inflammatory mediators, but their inhibitory abilities were weaker than those 1. Furthermore, 1, 3, strongly induced heme oxygenase-1. These results suggest potentially exert activity, may be considered to useful resource Copyright © 2015 John Wiley & Sons, Ltd.