The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome

• DOI: 10.1002/ptr.6166
• Publication Date: 2018-07-31T06:49:18Z
• Authors: Masoud Khorshidi; Ashraf Moini; Elham Alipoor; Neda Rezvan; Sattar Gorgani‐Fi...; Mehdi Yaseri; Mohammad Javad Ho...
• Keywords: Resistin; Homeostatic model assessment

The aim of this study was to investigate the effect quercetin on metabolic and hormonal parameters as well plasma concentration gene expression resistin in overweight or obese women with polycystic ovary syndrome (PCOS). In randomized, double‐blind, placebo‐controlled trial, 78 (25 ≤ BMI 40 kg/m 2 , 20–40 years) PCOS were recruited. Patients randomized receive 1,000 mg/day placebo for 12 weeks. Resistin peripheral blood mononuclear cells, glucose homeostasis, circulatory testosterone, luteinizing hormone (LH), sex hormone‐binding globulin, anthropometries assessed at baseline end study. Following supplementation, significantly decreased (2.07 ± 0.23 vs. 2.88 0.40 ng/ml, p < 0.001) mRNA level (0.64 0.58 1 0.56 fold change, = 0.008), compared group. Moreover, testosterone (0.72 0.15 0.76 0.12 LH (8.05 8.77 1.99 mIU/ml, 0.035) concentrations lower Fasting ( 0.001), insulin 0.02), homeostatic model assessment resistance 0.009) within group; however, no significant differences observed group 0.074, 0.226, 0.22, respectively). Quercetin supplementation levels expression, PCOS.