Effects of saffron supplementation on oxidative/antioxidant status and severity of disease in ulcerative colitis patients: A randomized, double‐blind, placebo‐controlled study

• DOI: 10.1002/ptr.6848
• Publication Date: 2020-10-05T05:22:38Z
• Authors: Negin Tahvilian; Mohsen Masoodi; Amirhossein Faghi...; Mohammadreza Vafa; Naheed Aryaeian; Azadeh Heydarian; AghaFateme Hosseini; Nariman Moradi; Farnaz Farsi
• Keywords: Malondialdehyde; Placebo-controlled study

Supplementation with saffron helps improve antioxidant status. Oxidative stress plays an important role in ulcerative colitis (UC). The present study aimed to investigate the effect of supplementation on disease severity and Oxidative/Antioxidant factors patients UC. This randomized double‐blinded was conducted 80 mild moderate UC patients. Participants were randomly divided into intervention (100 mg saffron/daily) placebo maltodextrin/daily) groups. Of all participants, 75 completed study. After 8 weeks, there significantly increased mean score simple clinical activity index questionnaire (3.83 ± 1.78 3 1.60, p = .004), serum levels total capacity (2.68 0.90 2.79 0.87, .016), superoxide dismutase (60.69 9.59 66.30 10.79, .009) glutathione peroxidase (22.05 14.27 29.67 17.97, .011) received compared group. Whereas, no significant difference malondialdehyde between two Finally, dietary as alternative therapy may effective improving reducing