Synergistic effect of combined treatment with baicalin and emodin on DSS‐induced colitis in mouse

• DOI: 10.1002/ptr.7230
• Publication Date: 2021-08-11T12:57:12Z
• Authors: Bo Xu; Shaowei Huang; Yanping Chen; Qing Wang; Shuang Luo; Yanyang Li; Xiaojing Wang; Jinyan Chen; Xia Luo; Lian Zhou
• Keywords: Baicalin

The treatment of combination drugs in complex diseases has been spotlighted. Ulcerative colitis (UC) is a chronic inflammatory disease that made progress therapy. Baicalin, flavone from Scutellaria baicalensis Georgi. (Lamiaceae), and emodin, an anthraquinone derivative Rhei Radix et Rhizoma. (Polygonaceae), both have reported to possess antiinflammatory activities. Our study investigated whether combined with baicalin emodin had synergistic effect inhibiting inflammation. results showed at lower dose the same as two alone significantly alleviated symptoms dextran sulfate sodium (DSS)-induced mice, involving prevention loss body weight colon shortening, decrease activity index (DAI), intestinal damages. decreased expression CD14/TLR4/NF-κB pathway proteins increased PPAR-γ protein mice. Further vitro shown CD14, whereas PPAR-γ, which inhibited NF-κB exerted effects. Furthermore, compared using individually, more significant effects on CD14 PPAR-γ. Therefore, DSS-induced colitis.