Quercetin inhibiting the PD‐1/PD‐L1 interaction for immune‐enhancing cancer chemopreventive agent

• DOI: 10.1002/ptr.7297
• Publication Date: 2021-09-25T01:25:06Z
• Authors: Lei Jing; Jieru Lin; Yang Yang; Li Tao; Yuyin Li; Zhenxing Liu; Qing Zhao; Aipo Diao
• Keywords: Mice; 0303 health sciences; 03 medical and health sciences; Neoplasms; T-Lymphocytes; Programmed Cell Death 1 Receptor; Animals; Quercetin; CD8-Positive T-Lymphocytes; B7-H1 Antigen; 3. Good health

Targeting the PD‐1/PD‐L1 immune checkpoints has achieved significant positive results in treatment of multiple cancers. Quercetin is one most abundant dietary flavonoids found various vegetables and fruits, a wide range biological activities including immunomodulation. Here we report that quercetin dihydrate was screened shown to inhibit interaction. Treatment with promoted killing activity T cells on MDA‐MB‐231 NCI‐H460 cancer cells. Experiments using xenograft mouse model showed growth rate tumor volumes masses dihydrate‐treated mice were decreased. Immunohistochemistry tumors CD8, GZMB, IFN‐γ increased mice. These suggest attenuates inhibitory effect PD‐L1 by inhibiting interaction, which an exciting potential be used as chemopreventive agent.