miR‐3,178 contributes to the therapeutic action of baicalein against hepatocellular carcinoma cells via modulating HDAC10

• DOI: 10.1002/ptr.7613
• Publication Date: 2022-09-08T01:20:08Z
• Authors: Junan Qi; Jun Li; Beibei Bie; Mengjiao Shi; Mengchen Zhu; Jing Tian; Kai Zhu; Jin Sun; Yanhua Mu; Zongfang Li; Ying Guo
• Keywords: Baicalein

Hepatocellular carcinoma (HCC) is the most common type of hepatic malignancies with high mortality and poor prognosis. Baicalein, one major bioactive flavonoids isolated from Scutellaria baicalensis Georgi, which reported to have anti-proliferation effect in varying cancers, including HCC, whose underlying molecular mechanism still largely unknown. In this study, we found that baicalein significantly inhibited proliferation colony formation, blocked cell cycle, promoted apoptosis HCC cells MHCC-97H SMMC-7721 vitro reduced tumor volume weight vivo. Increased microRNA (miR)-3,178 levels decreased histone deacetylase 10 (HDAC10) expression were treated patients' tissues. HDAC10 was identified as a target gene miR-3,178 by luciferase activity western blot. Both treatment overexpression could downregulate protein inactivated AKT, MDM2/p53/Bcl2/Bax FoxO3α/p27/CDK2/Cyclin E1 signal pathways. Not only that, knockdown partly abolish effects restoration abated miR-3,178-mediated role cells. Collectively, inhibits viability, blocks induces regulating miR-3,178/HDAC10 pathway. This finding indicated might be promising for HCC.