Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1

• DOI: 10.1002/ptr.7831
• Publication Date: 2023-05-02T06:59:32Z
• Authors: Shun Wu; Dingchun Lu; Babu Gajendran; Qilan Hu; Jian Zhang; Shengquan Wang; Minzhen Han; Yini Xu; Xiangchun Shen
• Keywords: Diabetic Cardiomyopathy

Abstract Diabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism critical factor that affects the occurrence development of DCM. Additionally, upregulation/activation silent information regulation 2 homolog‐1 (SIRT1) has been shown protect against Tanshinone II A (Tan IIA), main active component Salviae miltiorrhizae radix et rhizome (a valuable Chinese medicine), protective effects cardiovascular disease diabetes. However, its role mechanisms diabetes‐induced cardiac dysfunction remain unclear. Therefore, we explored whether Tan IIA alleviates ERS‐mediated DCM via SIRT1 elucidated underlying mechanism. The results suggested alleviated pathological changes hearts diabetic mice, ameliorated cytopathological morphology cardiomyocytes, reduced cell death rate, inhibited expression ERS‐related proteins mRNA. agonist activities glucose‐regulated protein 78 (GRP78). Furthermore, opposite under inhibitor. knockdown was siRNA‐SIRT1 transfection, degree GRP78 acetylation increased. Cumulatively, inhibiting ERS upregulating expression.