Garlic‐derived compounds: Epigenetic modulators and their antitumor effects

• DOI: 10.1002/ptr.8108
• Publication Date: 2024-01-09T23:48:15Z
• Authors: Huan Zhang; Haichao Wang; Lin Qin; Shuye Lin
• Keywords: Diallyl trisulfide

Abstract Cancer is a highly heterogeneous disease that poses serious threat to human health worldwide. Despite significant advances in the diagnosis and treatment of cancer, prognosis survival rate cancer remain poor due late diagnosis, drug resistance, adverse reactions. Therefore, it very necessary study development mechanism formulate effective therapeutic interventions. As widely available bioactive substances, natural products have shown obvious anticancer potential, especially by targeting abnormal epigenetic changes. The main active part garlic organic sulfur compounds, which diallyl trisulfide (DATS) content highest, accounting for more than 40% total composition. garlic‐derived compounds been recognized as an antioxidant prevention treatment. However, molecular antitumor effect remains unclear. Recent studies identified compound DATS plays critical roles enhancing CpG demethylation or promoting histone acetylation inhibitor. Here, we review progress against through pathways.