Antiulcerogenic and analgesic effects of the Austroplenckia populnea extracts in mice

• DOI: 10.1002/ptr.932
• Publication Date: 2002-08-25T23:15:07Z
• Authors: L. N. Seito; R. Mazaro; L. C. Di Stasi
• Keywords: Celastraceae; Phytotherapy; Terpene; Tail flick test

Austroplenckia populnea (Reiss.) Lund. is a Brazilian Cerrado plant belonging to the Celastraceae family. Hexane and methanol extracts of leaves were investigated for their antiulcerogenic (ethanol indomethacin/bethanecol induced gastric damage) analgesic (writhing tail-flick tests) activities in mice. Acute toxic effects also evaluated. Oral administration both at dose 1000 mg/kg significantly reduced total area lesion, relative lesion ulcerative index ethanol-induced damage, but inactive indomethacin/bethanecol-induced damage test. A dependent effect was determined with hexane extract lesions The number contortions writhing test, immersion