Aggregation Induced Transition by Modulation of Substituent Groups on Rofecoxib Analogues and Multi‐Stimulus Response Properties

• DOI: 10.1002/slct.202300501
• Publication Date: 2023-05-02T12:30:50Z
• Authors: Nannan Chen; Yongbo Wei; Wei Liu; Tong Wu; Jingming Zhou; Yuqiu Ye; Zexin Wang; Yanbing Ke; Hong Jiang; Lijun Xie
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract Aggregation‐induced emission luminogens (AIEgens) have been widely investigated due to their promising applications in data storage, organic light‐emitting diodes, and deep tissue bioimaging as compared conventional fluorophores. In this work, we designed synthesized two novel rofecoxib analogues functionalized with different terminal groups (−NH 2 , −Br) on the benzene ring B. Interestingly, compound a‐3 −NH substituent shows aggregation‐caused quenching effect whereas 1 b‐3 −Br group displays aggregation‐induced (AIE) property which may be caused by twisted conformation restricted – stacking of according X‐ray single crystal diffraction analysis. These opposite results indicated that could great influence photophysical properties targets. Moreover, exhibited multi‐stimuli response luminescence behaviors under various external stimuli including solvatochromism, mechanochromism acidochromism. Furthermore, lipid droplets imaging investigation proved was capable achieving specific bioimaging. This work not only presents a better understanding structure‐fluorescent relationship based scaffold rofecoxib, but also provides new avenue for spectral modulation development MSR materials.