Ag‐Catalyzed, Selectfluor‐Mediated External Acid‐Free Minisci Reaction in Aqueous Solution

• DOI: 10.1002/slct.202300958
• Publication Date: 2023-05-11T05:43:32Z
• Authors: Wengui Wang; Yingyue Song; Shuya Xing; Jinfeng Li; Wei Feng; Xudong Qu; Shoufeng Wang
• Keywords: Selectfluor; Primary (astronomy)

Abstract A silver‐catalyzed Minisci‐type reaction is reported here. Alkylation of electron‐deficient N‐heterocycles achieved in aqueous solution through decarboxylative cross‐coupling aliphatic acids and N‐heteroarenes open air without external Brønsted acid. Selectfluor used as a mild oxidant. Different substituents on heterocycles are tolerated. Primary secondary alkyl could be introduced efficiently into the heteroarenes.