Parallel Manipulation of Bifunctional DNA Molecules on Structured Surfaces Using Kinesin‐Driven Microtubules
0301 basic medicine
03 medical and health sciences
DNA, Viral
Kinesins
Nanotechnology
Gold
Bacteriophage lambda
Microtubules
DOI:
10.1002/smll.200600112
Publication Date:
2006-06-21T12:58:43Z
AUTHORS (6)
ABSTRACT
AbstractWe have developed a technique to manipulate bifunctional DNA molecules: One end is thiolated to bind to a patterned gold surface and the other end is biotinylated to bind to a microtubule gliding over a kinesin‐coated surface. We found that DNA molecules can be stretched and overstretched between the gold pads and the motile microtubules, and that they can form dynamic networks. This serves as a proof‐of‐principle that biological machineries can be used in vitro to accomplish the parallel formation of structured DNA templates that will have applications in biophysics and nanoelectronics.
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