Dual Enlargement of Gold Nanoparticles: From Mechanism to Scanometric Detection of Pathogenic Bacteria

• DOI: 10.1002/smll.201100294
• Publication Date: 2011-05-09T16:37:02Z
• Authors: Cuong Cao; Lionel Cervera Go...; Le Ly Thuy Tram; Anders Wolff; Dang Duong Bang
• Keywords: Bimetallic strip

Abstract A mechanism of dual enlargement gold nanoparticles (AuNPs) comprising two steps is described. In the first step, AuNPs are enlarged by depositing Au atoms on their crystalline faces. this process, particles not only but they also observed to multiply: new nuclei formed budding and division particles. second a silver enhancement subsequently performed deposition newly generate bimetallic Au@Ag core–shell structures. The nanocatalysis greatly enhances electron density nanostructures, leading stronger intensity for colorimetric discrimination as well better sensitivity quantitative measurement. Based this, simple scanometric assay on‐slide detection food‐born pathogen Campylobacter jejuni developed. After capturing target bacteria, gold‐tagged immunoprobes added create signal solid substrate. then amplified resulting in strong color that can easily be recognized unaided eye, or measured an inexpensive flatbed scanner. paper, reported time. It provides valuable mechanistic insight into development cost‐effective format.