Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?

• DOI: 10.1002/smll.201100628
• Publication Date: 2011-06-01T08:51:39Z
• Authors: Yu Cheng; Joseph D. Meyers; Richard S. Agnes; Tennyson L. Doane; Malcolm E. Kenney; Ann‐Marie Broome; Clemens Burda; James P. Basilion
• Keywords: Molecular Imaging; Center (category theory)

EGF-modified Au NP–Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared untargeted conjugates. The hydrophobic photodynamic therapy drug Pc can be delivered efficiently into glioma tumors by EGF peptide-targeted NPs. Compared conjugates, EGF–Au tumor. This delivery system holds promise for future of a wider range therapeutic drugs treatment hard-to-reach cancers. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: publisher is responsible content functionality any supporting information supplied Any queries (other than missing content) should directed corresponding author article.