Synthesis of Manganese Ferrite/Graphene Oxide Nanocomposites for Biomedical Applications

• DOI: 10.1002/smll.201201427
• Publication Date: 2012-09-07T13:21:37Z
• Authors: Erwin Peng; Eugene Shi Guang ...; Prashant Chandras...; Chang‐Tong Yang; Jun Ding; Kai‐Hsiang Chuang; Jun Min Xue
• Keywords: Superparamagnetism; Sonication; Biocompatibility

Abstract In this study, MnFe 2 O 4 nanoparticle (MFNP)‐decorated graphene oxide nanocomposites (MGONCs) are prepared through a simple mini‐emulsion and solvent evaporation process. It is demonstrated that the loading of magnetic nanocrystals can be tuned by varying ratio oxide/magnetic nanoparticles. On top that, hydrodynamic size range obtained optimized sonication time during emulsion By fine‐tuning time, MGONCs as small 56.8 ± 1.1 nm, 55.0 0.6 nm 56.2 0.4 loaded with 6 11 14 MFNPs, respectively, successfully fabricated. order to improve colloidal stability in physiological solutions (e.g., phosphate buffered saline or PBS solution), further conjugated polyethylene glycol (PEG). Heating exposing samples an alternating field (AMF) show efficient hyperthermia agents. At concentrations low 0.1 mg Fe mL −1 under 59.99 kA m field, highest specific absorption rate (SAR) recorded 1588.83 W g for MFNPs. also promising resonance imaging (MRI) T contrast A relaxivity value ( r ) high 256.2 (mM Fe) s could achieved The cytotoxicity results PEGylated exhibit excellent biocompatibility suitable biomedical applications.