Gold Nanoparticles Downregulate Interleukin‐1β‐Induced Pro‐Inflammatory Responses

• DOI: 10.1002/smll.201201528
• Publication Date: 2012-10-30T08:07:20Z
• Authors: Vadim V. Sumbayev; Inna M. Yasinska; Cesar Pascual Garcia; Douglas Gilliland; Gurprit S. Lall; Bernhard F. Gibbs; David R. Bonsall; Luca Varani; François Rossi; Luigi Calzolai
• Keywords: Male; 0303 health sciences; Tumor Necrosis Factor-alpha; Blotting, Western; Caspase 1; Interleukin-1beta; R; Metal Nanoparticles; Cell Line; 3. Good health; Enzyme Activation; Mice, Inbred C57BL; Mice; Phosphatidylinositol 3-Kinases; 03 medical and health sciences; Animals; Humans; Gold; Signal Transduction

Interleukin 1 beta (IL-1β)-dependent inflammatory disorders, such as rheumatoid arthritis and psoriasis, pose a serious medical burden worldwide, where patients face lifetime of illness treatment. Organogold compounds have been used since the 1930s to treat rheumatic other IL-1β-dependent diseases and, though their mechanisms action are still unclear, there is evidence that gold interferes with transmission signalling. Here we show for first time citrate-stabilized nanoparticles, in size dependent manner, specifically downregulate cellular responses induced by IL-1β both vitro vivo. Our results indicate anti-inflammatory activity nanoparticles associated an extracellular interaction IL-1β, thus opening potentially novel options further therapeutic applications.